Imrecoxib

Imrecoxib was approved by China Food and Drug Administration (CFDA) on May 20, 2011. It was developed and marketed as 恒扬® by HengRui Pharmaceuticals.

Imrecoxib is a selective COX-2 inhibitor indicated for treatment of osteoarthritis.

恒扬® is available as tablet for oral use, containing 100 mg of free Imrecoxib, and the recommend dose is 100 mg twice daily.

General Information

Update Date:2016-03-14

Drug Name:
Imrecoxib
Research Code:
BAP-909
Trade Name:
恒扬®
MOA:
Selective cyclooxygenase-2 (COX-2) inhibitor
Indication:
Osteoarthritis (OA)
Status:
Approved
Company:
HengRui (Originator)
Sales:
ATC Code:
Approved Countries or Area

Update Date:2015-07-29

Approval Date Approval Type Trade Name Indication Dosage Form Strength Company Review Classification
2011-05-20 Marketing approval 恒扬 Osteoarthritis (OA) Tablet, Film coated 100 mg HengRui
Chemical Structure

Update Date:2015-08-27

Molecular Weight 369.48
Formula C21H23NO3S
CAS No. 395683-14-4 (Imrecoxib);
Chemical Name 4-(4-(methylsulfonyl)phenyl)-1-propyl-3-(p-tolyl)-1H-pyrrol-2(5H)-one
Imrecoxib (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
369.48 0 4 5 62.8 3.205±0.497
*:Calculated by ACD/Labs software V11.02.
Related Patents

Update Date:2015-08-31

Synthesis & Impurities

Update Date:2015-10-16


1. US7112605B2.


1. CN104193664A.

1
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity A C21H25NO4S 387.49 395683-22-4
2
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity B C18H16O4S 328.38 959003-56-6
3
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity C C27H29NO11S 575.58
4
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity D C20H21NO3S 355.45 498556-76-6
5
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity E C21H23NO3S 369.48 657418-91-2
6
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity F C21H21NO5S 399.46 896729-08-1
7
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Imrecoxib impurity G C21H25NO4S 387.49