Tebipenem Pivoxil
Tebipenem pivoxil was approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on Apr 22, 2009. It was developed and marketed as Orapenem® by Meiji Seika in Japan.
Tebipenem pivoxil is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. Carbapenems are a class of beta-lactam antibiotics, which act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. It is used to treat otorhinolaryngological infection, otitis media and bacterial pneumonia.
Orapenem® is available as granules for oral use, containing 100 mg Tebipenem pivoxil/g granules. According to the weight of children, 4 mg/kg, and twice a day after dinner.
Update Date：2016-05-16
- Drug Name：
- Tebipenem Pivoxil
- Research Code：
- L-084; ME-1211
- Trade Name：
- Orapenem®
- MOA：
- Carbapenem antibiotic
- Indication：
- Otitis Media; Otorhinolaryngological infection; Bacterial Pneumonia
- Status：
- Approved
- Company：
- Meiji Seika (Originator)
- Sales：
-
$16.7 Million (Y2015);
$18.2 Million (Y2014);
$23 Million (Y2013); - ATC Code：
Update Date：2016-05-16
| Approval Date | Approval Type | Trade Name | Indication | Dosage Form | Strength | Company | Review Classification |
|---|---|---|---|---|---|---|---|
| 2009-04-22 | First approval | Orapenem | Otitis Media, Otorhinolaryngological infection, Bacterial Pneumonia | Granule | 10% | Meiji Seika |
Update Date：2016-05-09
|
Molecular Weight | 497.63 | ||||||||||||
| Formula | C22H31N3O6S2 | |||||||||||||
| CAS No. | 161715-24-8 (Tebipenem Pivoxil); | |||||||||||||
| Chemical Name | (＋)-hydroxymethyl(4R,5S,6S )-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-3-{[1-(2-thiazolin-2-yl)-3-azetidinyl]thio}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate,2-pivalate | |||||||||||||
| Tebipenem Pivoxil （Free Acid/Base）Parameters： | ||||||||||||||
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| *：Calculated by ACD/Labs software V11.02. | ||||||||||||||
Update Date：2016-05-27
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