Morinidazole

Morinidazole was approved by China Food and Drug Administration (CFDA) on February 24, 2014. It was developed and marketed as 迈灵达® by Hansoh Pharmaceutical.

Morinidazole is a nitroimidazoles antibiotic indicated for the treatment of bacterial infections including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.

迈灵达® is available as 100ml solution for intravenous injection, containing 0.5 g of free Morinidazole. The recommended dose is 500 mg (100 mL injection) twice daily every 6-8 hours continuously for 5-7 days.

General Information

Update Date:2016-03-14

Drug Name:
Morinidazole
Research Code:
Trade Name:
迈灵达®
MOA:
Nitroimidazoles antibiotic
Indication:
Pelvic inflammatory disease; Appendicitis
Status:
Approved
Company:
Hansoh (Originator)
Sales:
ATC Code:
Approved Countries or Area

Update Date:2015-07-29

Approval Date Approval Type Trade Name Indication Dosage Form Strength Company Review Classification
2014-02-24 Marketing approval 迈灵达 Pelvic inflammatory disease,Appendicitis Injection 0.5 g Morinidazole per 100 mL Hansoh
Chemical Structure

Update Date:2015-08-27

Molecular Weight 270.29
Formula C11H18N4O4
CAS No. 92478-27-8 (Morinidazole);
Chemical Name 1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol
Morinidazole (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
270.29 1 8 6 96.3 -0.369±0.468
*:Calculated by ACD/Labs software V11.02.
Related Patents

Update Date:2015-08-31

Synthesis & Impurities

Update Date:2016-02-01

1
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Morinidazole Impurity A 62580-80-7
2
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Morinidazole Impurity B
3
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Morinidazole Impurity C 1176802-18-8
4
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Morinidazole Impurity D 693-98-1
5
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Morinidazole Impurity E 195304-86-0
6
Impurity Name: Molecular Formula: Molecular Weight: CAS No.:
Morinidazole Impurity F 195304-86-0