Adrogolide Hydrochloride

Adrogolide Hydrochloride has been in phase II clinical trials for the treatment of Parkinson's disease (PD) and cocaine abuse. However, this research has been discontinued.

This compound was originally discovered by Abbott, then licensed to DrugAbuse Sciences.

General Information

Update Date:2016-04-22

Drug Name:
Adrogolide Hydrochloride
Research Code:
A-93431.1; ABT-431; DAS-431
Trade Name:
MOA:
Dopamine receptor D1 agonist
Indication:
Parkinson's disease (PD); Cocaine abuse
Status:
Phase Ⅱ (Discontinued)
Company:
Abbott (Originator) , DrugAbuse Sciences
Sales:
ATC Code:
Chemical Structure

Update Date:2016-02-03

Molecular Weight 435.96
Formula C22H25NO4S • HCl
CAS No. 171752-56-0 (Adrogolide);
166591-11-3 (Adrogolide hydrochloride);
Chemical Name Benzo[f]thieno[2,3-c]quinoline-9,10-diol, 4,5,5a,6,7,11b-hexahydro-2-propyl-, 9,10-diacetate, hydrochloride (1:1), (5aR,11bS)-
Adrogolide (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
399.50 1 5 6 92.9 4.009±0.514
*:Calculated by ACD/Labs software V11.02.