Amelubant

Amelubant has been in phase II clinical trials by Boehringer Ingelheim for the treatment of cystic fibrosis, chronic obstructive pulmonay disease, bronchial asthma and rheumatoid arthritis. However, this research has been discontinued.

In 2002, orphan drug designation was received in E.U. for the treatment of cystic fibrosis.

General Information

Update Date:2016-04-26

Drug Name:
Amelubant
Research Code:
BIIL-284; BIIL-284-BS
Trade Name:
MOA:
Leukotriene B4 receptor antagonist
Indication:
Cystic fibrosis (CF); Chronic obstructive pulmonary disease (COPD); Bronchial asthma; Rheumatoid arthritis (RA)
Status:
Phase Ⅱ (Discontinued)
Company:
Boehringer Ingelheim (Originator)
Sales:
ATC Code:
Chemical Structure

Update Date:2016-01-18

Molecular Weight 538.63
Formula C33H34N2O5
CAS No. 346735-24-8 (Amelubant);
Chemical Name Carbamic acid, N-[[4-[[3-[[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxy]methyl]phenyl]methoxy]phenyl]iminomethyl]-, ethyl ester
Amelubant (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
538.63 3 7 12 101 6.457±0.504
*:Calculated by ACD/Labs software V11.02.